Journal article
Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice
RA Aogo, DS Khoury, D Cromer, T Elliott, J Akter, LG Fogg, AS Nair, UN Liligeto, MSF Soon, BS Thomas, CPS Pernold, AS Romanczuk, P Laohamonthonkul, A Haque, MP Davenport
International Journal for Parasitology | ELSEVIER SCI LTD | Published : 2018
Abstract
A major mechanism of host-mediated control of blood-stage Plasmodium infection is thought to be removal of parasitized red blood cells (pRBCs) from circulation by the spleen or phagocytic system. The rate of parasite removal is thought to be further increased by anti-malarial drug treatment, contributing to the effectiveness of drug therapy. It is difficult to directly compare pRBC removal rates in the presence and absence of treatment, since in the absence of treatment the removal rate of parasites is obscured by the extent of ongoing parasite proliferation. Here, we transfused a single generation of fluorescently-labelled Plasmodium berghei pRBCs into mice, and monitored both their disappe..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the Australian Research Council (grant DP120100064), the National Health and Medical Research Council (NH&MRC), Australia (grants 1082022 (to MPD, DC, AH), 1080001 (to MPD), 1028634 (to AH), 1028641 (to AH) and 1126399 (to AH)), and the Austra lian Centre for Immunotherapy and Vaccine Development. The University of New South Wales, Australia, provided the International Postgraduate Research Scholarship to RA. The University of Queensland, Australia, provided International Postgraduate Research Scholarships to JA, and QIMR Berghofer Medical Research Institute, Australia, provided an International PhD studentship to MSFS. The authors do not have commercial or other associations that might pose a conflict of interest.